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PKC beta II inhibitor H6
CAS No. 1046787-18-1
PKC beta II inhibitor H6( —— )
Catalog No. M10233 CAS No. 1046787-18-1
PKC-IN-1 is a poent PKC beta II inhibitor with Ki of 14.9 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 312 | Get Quote |
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| 50MG | 1341 | Get Quote |
|
| 100MG | 1791 | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NamePKC beta II inhibitor H6
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NoteResearch use only, not for human use.
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Brief DescriptionPKC-IN-1 is a poent PKC beta II inhibitor with Ki of 14.9 nM.
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DescriptionPKC-IN-1 is a poent PKC beta II inhibitor with Ki of 14.9 nM, extracted from patent WO 2008096260 A1 as compound example H6.
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In VitroPKC-IN-1 (Compound A) is a potent, ATP-competitive and reversible of conventional PKC enzymes with Kis of 5.3 and 10.4 nM for human PKCβ and PKCα, and IC50s of 2.3, 8.1, 7.6, 25.6, 57.5, 314, 808 nM for PKCα, PKCβI, PKCβII, PKCθ, PKCγ, PKC mu and PKCε, respectively.
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In VivoPKC-IN-1 (Compound A; 15 and 30 mg/kg, p.o., bid (twice a day)) dose-dependently and significantly reduces maximum EAE severity and end severity in autoimmune encephalitis (EAE) model in Lewis rats.
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Synonyms——
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PathwayAngiogenesis
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TargetPKC
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RecptorPKC
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1046787-18-1
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Formula Weight500.623
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Molecular FormulaC25H37FN8O2
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 25 mg/mL 49.94 mM
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SMILESCC1CN(C(CN1C(=O)N2CC3=C(C2(C)C)NN=C3NC4=NC(=NC=C4F)C)C)CC5CCOCC5
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Chemical Name((2S,5R)-2,5-dimethyl-4-((tetrahydro-2H-pyran-4-yl)methyl)piperazin-1-yl)(3-((5-fluoro-2-methylpyrimidin-4-yl)amino)-6,6-dimethyl-4,6-dihydropyrrolo[3,4-c]pyrazol-5(1H)-yl)methanone
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. 3-Aminopyrrolo[3,4-c]pyrazole-5(1H,4H,6H)carboxaldehyde derivatives as PKC inhibitors and their preparation, pharmaceutical compositions and use in the treatment of diseases. From PCT Int. Appl. (2008), WO 2008096260 A1 20080814.
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